Drug Discovery Research Screening Libraries
AdipoGen Octadecanoylamino fluorescein
Chemical. CAS 110698-53-8. Formula C38H47NO6. Molecular Weight 613.78. 5-Octadecanoylaminofluorescein is a lipophilic/amphiphilic fluorescent probe useful in monitoring membrane lipid behaviour and fluorescence resonance energy transfer applications in life cells. It binds at amphiphitic interfaces and may be used as probe for studies of interfacial micropolarity, micro fluidity and local pH. The label makes the cell membrane bright green. Spectral data lambdaex 497 nm lambdaem 520±10 nm in ethanol.
AdipoGen Tianeptine sodium salt
Chemical. CAS 30123-17-2. Formula C21H24ClN2O4S . Na. MW 435.9 . 23.0. Synthetic. Tianeptine is an atypical antidepressant with diverse actions, most notably on the glutamatergic system. It is a selective facilitator of 5-HT serotonin uptake in vitro and in vivo. It attenuates glutamate release and modulates the function of the AMPA receptor. Tianeptine also acts as an agonist of the µ-opioid receptor EC50s = 194 and 641nM for human and mouse receptors, respectively. Might have anti-inflammatory properties through modulation of TLR and NLRP3 inflammasome signaling pathways.
Apexbio Technology LLC DiscoveryProbe™ Neuronal Signaling Compound Library Plus, 250uL/well(10 mM solution),96 Well Racks With Screw Cap
DiscoveryProbe™ Neuronal Signaling Compound Library Plus is a unique collection of 948 neuronal signaling-related small molecules for neuroscience reasearch. Available in stock with overnight delivery and free shipping over $500 Cost-effective and competitive price to save your findings Potent, selective and cell-permeable in inhibiting or activating target molecules Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.) Detailed files describing potency, selectivity and applications etc. Supported by published data from top peer-reviewed journals Guaranteed high quality with NMR and HPLC validation. Other sizes are also available. Please inqury us for quote.
AdipoGen Capsaicin from Capsicum annuum
Chemical. CAS 404-86-4. Formula C18H27NO3. MW 305.41. Synthetic. Primary active component of the heat and pain-eliciting lipid-soluble fraction of Capsicum pepper. Acts as an agonist at the vanilloid receptor VR1 TRPV1 receptor, a ligand-gated non-selective cation channel. Capsaicin elicits a sensation of burning pain by activation of TRPV1 on small, non-myelinated polymodal C-type nociceptive nerve fibers. It has been shown to have antinociceptive, anti-inflammatory, anti-obesity, neuroprotective and anticancer effects.
AdipoGen Dimethyl fumarate
Chemical. CAS 624-49-7. Formula C6H8O4. MW 144.1. Immunomodulatory and anti-inflammatory agent used in patients with relapsing-remitting multiple sclerosis MS and psoriasis. Causes an immune switch characterized by induction of anti-inflammatory/regulatory innate and adaptive immune cell populations such as regulatory T cells Tregs and inhibition or apoptosis of pro-inflammatory cells, such as T helper 1 Th1 and Th17 subsets. Blocks immune cell activation through inhibition of glycolysis via post-transcriptional modification succination of glyceraldehyde 3-phosphate dehydrogenase GAPDH in vitro and in vivo and is therefore a useful agent for immunometabolism research. GAPDH catalyzes the conversion of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate during glycolysis, an essential metabolic pathway where glucose is converted to pyruvate, to fuel the TCA cycle and oxidative phosphorylation OXPHOS for the production of adenosine triphosphate ATP as an energy source.
AdipoGen Biotin-XX
Chemical. CAS 89889-51-0. Formula C22H38N4O5S. Molecular Weight 470.63. Biotinylated cross-linking reagent. Biotin-XX has a 14 atom spacer designated by XX to facilitate reactivity with the molecule and eventual accessibility of the biotin to avidin or streptavidin.
AdipoGen Acetamidofluorescein
Chemical. CAS 82779-14-4. Formula C22H15NO6. MW 389.36. Acetamidofluorescein is a N-acetyl derivative of fluorescein that is strongly fluorescent und used as a fluorescent label. Spectral data lambdaex = 491nm, lambdaem 515nm.
Selleck Chemical LLC Tyrosine Kinase Inhibitor Library 100uL/well
A unique collection of 513 tyrosine kinase inhibitors for high throughput screening (HTS) and high content screening (HCS). *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Apexbio Technology LLC DiscoveryProbe™ Tyrosine Kinase Inhibitor Library, 250uL/well(10 mM solution),96 Well Racks With Screw Cap
A unique collection of 369 tyrosine kinase inhibitors for high throughput screening (HTS) and high content screening (HCS). Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC DiscoveryProbe™ Autophagy Compound Library, 250uL/well(10 mM solution), 96 Well Racks With Screw Cap
A unique collection of 486 autophagy-related compounds for autophagy research. Other sizes are available. Please inqury us for quote.
AdipoGen DNER ED hFc h rec
Protein. The extracellular domain of human DNER aa 29-637 is fused at the C-terminus to the Fc portion of human IgG1. Source HEK 293 cells. Endotoxin content <0.06EU/µg purified protein LAL test Lonza. Lyophilized from 0.2µm-filtered solution in PBS. Purity >90% SDS-PAGE. DNER is an activator of the Notch1 pathway. It mediates neuron-glia interaction during astrocytogenesis.
Apexbio Technology LLC DiscoveryProbe™ NF-B Signaling Library, 100uL/well(10 mM solution), 96 Well Racks With Screw Cap
A unique collection of 73 NF-B inhibitors for NF-B signaling pathway research. Other sizes are available. Please inqury us for quote.